Omics technologies (such as genomics and proteomics) reveal disease-related molecular characteristics through high-throughput data, but using them is challenging due to data heterogeneity and a lack of standardization (Liu X
Machine learning permits both the large-scale efficient and generalizable application and addressing the complex dynamics of such relationships that the machine learning algorithms can decipher
10.1105/tpc.111.083998 Plant Cell 9 Geu-FloresF.NielsenM.NafisiM
J Drug Target (2002) 10:28596
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Indeed, several landmark clinical trials, such as the Scandinavian Simvastatin Survival Study (4S) (4), Cholesterol and Recurrent Events (CARE) (5), Long-term Intervention with Pravastatin in Ischemic Disease (LIPID) (6), West of Scotland Coronary Prevention Study (WOSCOPS) (7), Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS) (8), Heart Protection Study (HPS) (9), and the Anglo-Scandinavian Cardiac Outcome Trial Lipid-lowering Arm (ASCOT-LLA) (10), have demonstrated the benefit of lipid lowering with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors or statins for the primary and secondary prevention of CHD
