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Preferential accumulation at injury sites suggests active homing mechanisms or increased vascular permeability and tissue binding at sites of damage, though specific mechanisms governing injury-site localization remain under investigation

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References National Center for Biotechnology Information (NCBI) Human Chorionic Gonadotropin: structure, function, and LH receptor binding mechanisms Seminars in Reproductive Medicine Pharmacokinetics and pharmacodynamics of HCG: extended halflife and sustained activity Translational Andrology and Urology (2018) Lee JA & Ramasamy R: Review of hCG for hypogonadal male infertility (typical regimens: 1,5005,000 IU 23/week) The Journal of Clinical Endocrinology & Metabolism (2005) Coviello AD et al: Lowdose hCG maintains intratesticular testosterone in men with testosteroneinduced gonadotropin suppression Male Infertility Guide Clinical commentary on hCG dosing: 500 IU SC 3/week for maintenance

Run once daily with gradual titration across the cycle