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It leads to a drastic expansion of the hearts size, which puts a considerable amount of pressure on its chambers

Because of similar pharmacological properties, it is reasonable to expect similar risk with the concomitant use of other CNS depressant drugs with opioid analgesics (see PRECAUTIONS, Drug Interactions)

Rather than reducing cravings or changing alcohols rewarding effects, it works by creating a strong physical deterrent to drinking

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It provides a steadier signal to the pituitary, leading to a significant rise in both GH and, consequently, Insulin-like Growth Factor 1 (IGF-1)