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Mounjaro (tirzepatide) is a dual-action medication mimicking both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide)

They are powerful hormonal medications that alter appetite signalling, gastric emptying and insulin response at a systemic level

Pancreatic ductal epithelial cells do not appear to express GLP-1Rs (73, 85)

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Peer review Peer review information Nature Aging thanks Christian Hlscher, Tami Rubinek and Marc Schneeberger for their contribution to the peer review of this work

[7] These conditions demonstrate that when metabolic changes are significant and pathological, they can indeed influence bowel patterns