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At the time of this writing, liraglutide is the only GLP-1 RA with a labeled indication to reduce the risk of major adverse cardiovascular events (MACE), yet several other GLP-1 RAs have shown significant reduction in MACE, as summarized in Table 2

This milestone marks the initiation of the first Phase 3 clinical trial of Bofanglutide injection worldwide for the treatment of T2DM

Liraglutide attenuates diabetic cardiomyopathy via the ILK/PI3K/AKT/PTEN signaling pathway in rats with streptozotocin-induced type 2 diabetes mellitus

Approval by the Food and Drug Administration is likely years away for most

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Individual results vary based on starting weight, metabolic health, adherence to lifestyle modifications, genetic factors, and concurrent medications