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Clinically, anxiety disorders encompass disorders such as generalized anxiety disorder (GAD), panic disorder, specific phobias, and social anxiety disorder (SAD), all marked by fear responses, behavioral avoidance, and heightened nervous arousal in perceived threatening situations (Wu et al., 2025)

This conversion creates a recycling pathway known as the citrulline-NO cycle, where NOS (nitric oxide synthase) enzymes transform L-arginine into NO and L-citrulline

and group 8: mice administered Dihexa, both through injection to the gastrocnemius muscle

It is important to mention that these O 2 levels do not represent the concentrations found inside human healthy and cancerous tissues and are followingly used to investigate the different therapeutic efficiency of the nanoparticle formulation in high and low O 2 atmospheres

Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess

10.2353/ajpath.2008.070583 Am