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15 In mammals, this process is catalyzed by enzymes encoded by genes such as CntA/B, CutC, and betaine reductase

doi:10.3389/fendo.2021.721135 20

The fibrotic effects of TMAO on human renal fibroblasts is mediated by NLRP3, caspase-1 and the PERK/Akt/mTOR pathway