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Plant-derived bioactive substances, including polyphenols (flavonoids, phenolic acids, anthocyanins), polysaccharides (inulin, fructooligosaccharides, plant polysaccharides), saponins (ginsenosides, astragaloside IV), and alkaloids (berberine), have been shown to possess multiple biological activities such as gut microbiota modulation, intestinal barrier improvement, reduction of inflammatory factor release, and antioxidant effects ( Probiotics and prebiotics, as nutritional intervention approaches for gut microbiota modulation, have shown promising application prospects in DKD management
The most commonly reported adverse events were gastrointestinal, including nausea, diarrhoea, vomiting, and constipation, and were generally mild to moderate in severity
Immediate medical attention is warranted if missed periods are accompanied by concerning symptoms such as severe abdominal pain, heavy bleeding, abnormal vaginal discharge, signs of pregnancy, symptoms of thyroid dysfunction (significant fatigue, cold intolerance, hair loss), or signs of hyperprolactinaemia (galactorrhoea, visual disturbances, headaches)