Regular monitoring should include weight checks, renal function, gastrointestinal symptoms, and coordination with haematology-oncology teams
Key Points Obesity results from genetic and environmental factors that interfere with the action of brain and peripheral networks involved in regulating energy balance The control of energy expenditure is, in part, exerted on the activity of brown adipose tissue, which might have a considerable thermogenic effect in the body The controls of energy intake and expenditure are insured by interrelated cortical executive, reward and autonomic circuits in the brain The dopamine mesolimbic circuit and the opioid, endocannabinoid and melanocortin systems are key central nervous system elements in energy homeostasis Leptin and ghrelin are peripheral homeostatic hormones that signal to the brain to provide information on energy balance and nutritional status Abstract Obesity ensues from an imbalance between energy intake and expenditure that results from geneenvironment interactions, which favour a positive energy balance
Months 612: Long-Term Progress and Maintenance Many patients continue losing weight throughout the second half of the first year, although the rate of weight loss often slows compared with the earlier months
Pregnancy itself changes medication metabolism and transfer across the placenta, adding another layer of safety concern
Kimple, M
Recently, Szopa et al
