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The Kraus 2014 Nature paper established that NNMT is highly expressed in adipose tissue (especially in obesity) and that NNMT knockdown in adipose protects against diet-induced obesity in mice

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Ultrasound imaging is warranted

Microscopic examination found no changes in liver, spleen, lung, kidney, brain, thymus, or reproductive organs

However, the results of a trial with the drug Liraglutide absolutely put the nail in the coffin for this theory