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Dosing tiers: Start at 250 mcg on the first injection to assess tolerance

We go over your health history, the medications you take, your weight-related concerns, and whether you meet the criteria to begin

Your provider screens for this during evaluation it is a firm contraindication, not a discretionary one

Frequently Asked Questions Glossary of Terms References What Is Retatrutide and How Does It Work

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Key considerations when switching: Allow a washout period based on tirzepatide half-life Start retatrutide at the standard 1mg initiation dose regardless of previous tirzepatide dose Expect renewed GI side effects as the glucagon receptor is a new stimulus Monitor heart rate more carefully during the initial escalation period When tirzepatide is the better choice Tirzepatide remains the superior option in several specific situations