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Despite advances in symptomatic therapies such as dopamine replacement therapy and deep brain stimulation, disease-modifying therapies have so far been found that could slow or stop neurodegeneration in PD patients [55]

Tirzepatide (515 mg weekly) evaluated over 52 weeks in the SYNERGY-NASH trial with participants having MASH and stage F2 or F3 fibrosis showed MASH resolution without worsening fibrosis in 44%, 56%, and 62% of participants on 5 mg, 10 mg, and 15 mg doses, respectively, compared to 10% with placebo [102,107]

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Several of the peptides discussed have potential relevance to psoriatic arthritis

After APAP administration, however, the decrease in GJ expression in hepatocytes of hepsin / mice was more gradual compared with that in wild-type mice