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Miki N, Ono M, Shizume K

Adult Dosing Dosage may vary based on different medical indications: For the initial treatment of vitamin B12 deficiency, the usual dose is 1000mcg SC/IM, given once a day for 1 week, followed by 1 dose a week for 1 month

As an organic salt, CM and is formed through the combination of L-citrulline (C 6 H 13 N 3 O 3 ), a non-essential amino acid involved in the urea cycle, and malate (or malic acid, C 4 H 6 O 5 ), a tricarboxylic acid (TCA) intermediate (Bendahan et al

Duration Side effects Common side effects include nausea, diarrhea, constipation, vomiting, injection site reactions, and low blood sugar

289 One limitation of ASNase therapy, which promotes tumor cell death by systematically lowering the asparagine concentration, is that it impairs ASN requirements in normal immune cells

P Natl Acad Sci USA