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There were two coprimary composite CV endpoints: Patients were randomized to either LANTUS (N=6,264) titrated to a goal fasting plasma glucose of 95 mg/dL or to standard care (N=6,273)

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By contrast, no significant differences were observed in response to GEP12 at 5 nmol/kg/day (food intake: mean difference 20.0 kcal/day, 95% CI 41.4 to 1.5 kcal/day, p = 0.067

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116118 Deng et al found that TMAO may induce neuroinflammation and neuronal apoptosis, leading to NVU dysfunction, which in turn exacerbates cognitive impairment and neuropathological changes in vascular dementia rats

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