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native IGF-1, extending half-life to ~2030 hoursActivates PI3K/Akt/mTORC1 pathway, stimulating protein synthesis and inhibiting catabolismMAPK/ERK activation drives muscle satellite cell proliferation and differentiationPromotes GLUT4 translocation and enhanced glucose uptake in muscle cellsWidely used in cell culture optimization to enhance proliferation and viability Bottom line: IGF-1 LR3 is a potent research compound that operates at the intersection of growth hormone biology, muscle physiology, and metabolic regulation

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[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Gupta V

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