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The mechanism of action is well-characterized and makes biological sense

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A recent study demonstrated the ability of a dendrimer-conjugated NAC (D-NAC) to specifically target glial and astrocyte cells, indicating potential to alter GSH levels in specific cell populations without altering levels throughout the CNS ( One of the most well-established properties of GSH is its role in maintaining redox homeostasis, but it is also emerging as a mediator of redox signaling through mechanisms such as protein S-glutathionylation and/or GSNO-mediated protein S-nitrosylation (Zhang and Forman, 2012)

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Vegetarians and vegans typically have lower dietary intake, which is why supplementation may show more noticeable benefit in these groups