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Diagnosis can be further confirmed by demonstrating reduced carnitine transport in skin fibroblasts in the patient or by mutation analyses of the SLC22A5 gene

Regarding the cancer chemo-preventive activities, it has been shown that HOTYR is able to inhibit both initiation and promotion/progression phases of carcinogenesis by preventing the DNA damage induced by different genotoxic molecules and by inhibiting proliferation and inducing apoptosis in different tumors cell lines, respectively (73, 74)

Stearoyl-CoA desaturase 1 (SCD1) is an iron-containing endoplasmic reticulum-binding enzyme that can modify lipids and play an essential role in synthesizing saturated fatty acids (SFAs) and MUFAs

J Endocrinol2016;230:R518

Its also unknown if these beneficial effects extend to humans

Ideal candidates typically have BMI 27 with weight-related comorbidities or BMI 30, are motivated for lifestyle integration, and have no contraindications