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HFpEF: Heart Failure with Preserved Ejection Fraction

The concentration genuinely drops more between doses

SPRINT MIND Investigators, 2019), and the lack of conclusive evidence of effect from these trials may be in part attributable to the variation in blood pressure target levels and the assessment of cognitive outcomes (SPRINT MIND Investigators, 2019)

Include any medical reasons why step therapy medications are contraindicated

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According to the company and consistent with published pre-clinical literature, it has been studied in animal models for pre-clinical signals related to the gastrointestinal environment, inflammatory responses in the GI tract, and tissue-related processes in tendon and joint contexts - all per pre-clinical animal data, not established human clinical outcomes