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Reported plasma levels of phenformin after 50-100 mg of phenformin uptake in patients are ~1.7 M 67 , while tissue concentrations have not been assessed but are expected to be much higher as reported in animal models 68

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Some people deliberately schedule their injection to begin a new 7-day cycle on Sunday evening, knowing that any weekend social drinking will occur in the later half of the cycle when drug levels are naturally declining

Ethics declarations Competing interests K.L.J

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