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The Case for Localized Injections The logic here is straightforward: deliver the compound as close to the site of injury as possible

Neurological Relevance Preclinical evidence suggests broader neuroprotective potential: In traumatic brain injury models, SS-31 reduced mitochondrial swelling, neuronal loss, and neuroinflammation Aged mice treated with SS-31 showed significantly improved exercise tolerance, muscle strength, and mitochondrial efficiency Studies demonstrate protection against ischemic injury and enhanced cardiac output Phase 3 trials are ongoing for dry age-related macular degeneration and primary mitochondrial myopathy (Stealth BioTherapeutics pipeline) Implications for Brain Aging Mitochondrial dysfunction is a hallmark of brain aging and neurodegeneration

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Repeated injections in the same spot cause lumps (lipohypertrophy) and reduce absorption

TABLE 2 Compounds Structure, Bioactivities, and Molecular mechanism of Alkaloids and Polyphenols