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MYCN -amplified HR-NB tumors, which have high metabolic needs, are dependent on iron and cysteine (key for glutathione production), making them potentially sensitive to ferroptotic cell death 7,8,9

In hepatocellular carcinoma, the combination of m6A inhibitors with sorafenib or lenvatinib reverses drug resistance ( 6.2 The SSP as a key metabolic pathway mediating resistance to conventional chemotherapy and targeted therapy The SSP serves as a pivotal metabolic pathway that mediates tumor resistance to conventional chemotherapeutic agents and targeted therapeutics

[DOI] [PubMed] [Google Scholar] 145.Chethan G.E., Garkhal J., De U.K

By deeply integrating high-content zebrafish phenotypic data with multi-omics profiles (e.g., transcriptomics, proteomics, and metabolomics), and leveraging graph neural networks with multi-task learning algorithms, a virtual zebrafish efficacy prediction platform can be built (Figure 6B) (Garg and Geurten, 2024)

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