These findings suggest that co-targeting the AR and PI3K/AKT pathways may overcome resistance mechanisms and offer a promising therapeutic strategy for advanced, PTEN-deficient prostate cancer [84]
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PLoS Biol 13(10):e1002277 Haze K, Yoshida H, Yanagi H, Yura T, Mori K (1999) Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
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