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Consistently, the relative risk of colistin-induced kidney damage, calculated based on histological analysis as well as by the early marker of tubular kidney injury, Kim-1, was halved under co-administration with L-carnitine in vivo

This metabolic profile is identical to that observed in isolated sulfite oxidase deficiency (ISOD), an inherited condition caused by mutations in the SUOX gene that codes for sulfite oxidase (29)

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[DOI] [PMC free article] [PubMed] J.N., H., A., S., 2006