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(Bethesda, MD: ClinicalTrials.gov) (2025)

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It addresses why metabolism slows, not just how to force fat loss despite a struggling metabolism

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(2) lipase inhibitors (orlistat)

The one piece of cleaner support is Sun 2021 (PMID 34827486), an independent group's APP/PS1 mouse study reporting improved Morris water maze performance, increased synaptophysin, and reduced IL-1/TNF- via PI3K/AKT