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Most participants experienced well-known side effects such as nausea, vomiting, diarrhea, or constipation

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Horai Y, Nakamura H, Nakashima Y, Hayashi T, Kawakami A

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The trending decline in the junctional zone could be affecting the labyrinth layer, as placentas with decreased spongiotrophoblasts and glycogen cells (both found in the junctional zone) are shown to induce decreased proliferation and a surge in apoptosis in the labyrinth layer [50, 61]