This was evident when comparing exenatide and semaglutide chromatographic profiles: exenatide, a non-lipidated peptide with several acidic residues, was strongly affected by NSA (likely due to ionic and dipole-ionic interactions with metal surfaces), leading to decreased efficiency
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Of those who were taking semaglutide for diabetes treatment, there was an incidence of 8.9% of NAION-related events, compared to 1.8% who were not taking any GLP-1based medications
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