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Circulating iron uptake in the form of two ferric iron (Fe 3+ ) bound to transferrin (TF) is achieved by binding to transferrin receptor protein 1 (TFR1) and subsequently triggering endocytosis [70]

Similar patterns of FTH1 upregulation and TfR1 downregulation have also been reported in primary murine chondrocytes under iron overload (93) and in cartilage tissue from OA models (94)

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Autophagy is an intracellular degradation process responsible for eliminating proteins, misfolded or damaged organelles, and aged cellular components

Study of DNA damage via the comet assay and base excision repair activities in rat brain neurons and astrocytes during aging

BPC-157 is a naturally occurring peptide studied for its observed effects on fibroblast proliferation, gastrointestinal epithelial integrity, tendon extracellular matrix remodeling, and inflammatory marker modulation