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One placebo-controlled study examined the effect of lipoic acid on the visual capability of 80 participants of whom 12 had type 1 diabetes, 48 had type 2 diabetes, and 20 were diabetes-free

Ryan JL, Heckler CE, Ling M, Katz A, Williams JP, Pentland AP, Morrow GR (2013) Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients

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When you add significant caloric restriction to an already-depleted NAD+ system, the cellular energy shortfall compounds

It was designed with a smooth interior surface contoured towards the tip to reduce fluid loss in the tip to a negligible volume

Common side effects include nausea, vomiting, diarrhea, and constipation, which typically diminish with dose adjustment