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Certain factors may increase the likelihood of experiencing bloating on GLP-1 therapy, including: Pre-existing gastrointestinal conditions such as irritable bowel syndrome (IBS), functional dyspepsia, or small intestinal bacterial overgrowth (SIBO) Rapid dose escalation without adequate titration periods Dietary factors , particularly high intake of fermentable carbohydrates (FODMAPs), fatty foods, or carbonated beverages Concurrent medications that affect gastrointestinal motility Patients should be aware that GLP-1 receptor agonists have been associated with more serious gastrointestinal adverse effects, including pancreatitis (inflammation of the pancreas) and gallbladder disease

The very first package insert for Lovastatin in 1983 addressed the issue of statin intolerance and mysositis as has every ACC guidelines since

doi: 10.5021/ad.24.043

Fan D, Wu X, Dong W, Sun W, Li J, Tang X

Research suggests that most patients who discontinue GLP-1 therapies regain a significant portion of their lost weight within a year, particularly if they do not maintain rigorous lifestyle changes

Side effects are rare but may include mild discomfort at the injection site