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In hEDS-associated neuropathic POTS where partial sympathetic denervation of the lower extremity vasculature produces blunted vasoconstriction, blood already pools in peripheral capacitance vessels on standing, stroke volume is structurally reduced, and the sympathetic nervous system is already operating near its compensation ceiling the additional vasodilatory and chronotropic load imposed by chronic dual incretin receptor agonism may have limited physiological reserve to absorb it

Detailed codes for outcomes are shown in Supplemental Table 2

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The provider reviews medical history, wellness goals, current medications, allergies, symptoms, possible contraindications, and clinical appropriateness

Closing Perspective Closing Perspective The modern health crisis is not defined by single nutrient deficiencies but by systemic oxidative overload