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The effect of glucagon-like peptide-1 (GLP-1) receptor agonists in persons with obesity and knee osteoarthritis in this population has not been well-established. To test the impact of a GLP-1 receptor weight loss medication on knee OA outcomes, Bliddal and colleagues conducted a double-blind, randomized, placebo-controlled trial at 61 sites across 11 countries

1-3 GIP receptors are found in the central nervous system (eg, pituitary gland, cerebral cortex, hippocampus, olfactory bulb), adrenal cortex, heart, adipose tissue, and bone