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It protects the structure and function of hepatocytes by inhibiting oxidative stress and inflammatory responses

This epigenetic modulation affects hundreds of genes involved in: Cell cycle regulation - promoting differentiation and reducing proliferation Healthy inflammatory response - suppressing NF-B and pro-inflammatory cytokines Barrier function - upregulating tight junction proteins Antimicrobial defense - increasing defensin and mucin production Metabolic regulation - enhancing mitochondrial biogenesis A Fine-Tuned Response The concentration-dependent nature of HDAC inhibition adds another layer of sophistication

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In the context of pyroptosis, ROS play roles in the activation of the NLRP3 inflammasome and caspases (Fig

5 It also helps transport toxic compounds generated within the mitochondria out of the cell to prevent their accumulation