Research in humans is a bit less impressive Clinical trials in humans A 1981 double-blind study found that chronic insomniac patients found that subjects slept 59% more, shorter sleep latency, and higher sleep efficiency (Schneider 1981) A 1987 double-blind study did not find any statistically significant changes in sleep structure as measured by REM sleep, NREM sleep, or total sleep time (Debellis 1987) A 1992 double-blind study in 14 chronic insomnia patients found higher sleep efficiency and subjectively estimated tiredness decreased to similar levels of healthy subjects in 7 nights of injections (Schneider 1992) There are some limitations to these studies however
By age 60, that concentration has fallen to approximately 80 ng/mL, a 60% decline that correlates directly with reduced healing capacity, collagen loss, and visible aging
Some early studies in animals have shown a potential risk to foetal development, which is why current advice is to avoid use in pregnancy and stop treatment well in advance of trying to conceive
Side effects are rare but may include injection-site pain, tingling, or mild dizziness
Pre-blends are easier to draw and inject, but you cannot raise one compound without raising the other
Elevated blood levels of homocysteine have been associated with cardiovascular risk