What we deemed The Biggest Breakthrough in OSA Since CPAP Bottom Line The FDAs approval of the Wegovy weight-loss pill represents a seminal moment in obesity care transitioning effective GLP-1 pharmacotherapy from injectables to a once-daily tablet
Key takeaways GLP-1 medications do not inherently cause muscle wasting. Most weight lost on semaglutide or tirzepatide is fat , not muscle. Some lean-mass loss during weight loss reflects adaptive remodeling , not pathology. Adequate protein intake and resistance training significantly reduce muscle loss during GLP-1 therapy. Do GLP-1 Medications Cause Muscle Wasting
Thats important because stabilized plaque is far less likely to rupture and cause a heart attack
Cardiovascular risks in type 2 diabetes and the interpretation of cardiovascular outcome trials
Areas of theoretical concern include: Glycaemic instability , particularly in those on antidiabetic medications Altered lipid metabolism , given GH's effects on fatty acid mobilisation Indirect cardiovascular effects , as elevated heart rate has been observed with glucagon receptor agonism and fluid retention is associated with GH excess [1] [17] There are no formal interaction data linking retatrutide and sermorelin to specific adverse outcomes, but the absence of evidence must not be interpreted as confirmation of safety
No head-to-head trial exists yet