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GHRH analogues such as sermorelin and CJC-1295, or GHRPs such as ipamorelin, amplify endogenous GH release without directly raising IGF-1 beyond physiologic feedback limits

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It also restricts the blood supply to the skin, affecting nutrition and oxygen supply

Cellular machinery cannot repair these busulfan-induced DNA damages and interferes with DNA replication and transcription of RNA, which prevents further cell division and ultimately leads to cytotoxic, mutagenic, and carcinogenic effects

Pflgers Archiv European Journal of Physiology