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While actively-targeted lipid-based systems for nucleic acid delivery have not been documented in clinical trials, several intravenously administered LNPs have reached the clinical evaluation with the therapeutic aim of delivering nucleic acids to liver [90]

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Cardiac procedures requiring cardiopulmonary bypass (CPB) have an acute renal failure incidence of up to 30%, with up to 6% of patients requiring renal replacement therapy, significantly increasing perioperative mortality [67]

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