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Grima G, Benz B, Parpura V, Cunod M, Do KQ

Preclinical study in mice with streptozotocin-induced diabetes that showed glucose-independent amelioration of kidney fibrosis with the DPP-4 inhibitor linagliptin

In addition, in vitro models of primary human adipose stem cells, researchers detected intracellular fat content and quantitative expression of early and mature adipocyte markers (PPAR, FABP4, and HSL), demonstrating that glucagon can significantly reduce adipocyte differentiation, inhibit adipocyte proliferation and adipogenesis

Commercially available GLP1/GIP was granted FDA approved for weight loss in 2023

Our search across three databases yielded N = 7275 papers

Disruption of these pathways frequently results in involuntary movements