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Early brain overgrowth in autism associated with an increase in cortical surface area before age 2 years

During preclinical investigations, they have shown some similar potential benefits

Arch Ital Biol 155(4):131141 Genis L, Dvila D, Fernandez S, Pozo-Rodriglvarez A, Martnez-Murillo R, Torres-Aleman I (2014) Astrocytes require insulin-like growth factor I to protect neurons against oxidative injury

To eliminate bias caused by the order of rows in the covariate matrix, the row order was randomized

For a biologic, this means characterizing the protein sequence, glycosylation pattern, expression system, downstream purification process, and all mechanism-of-action claims associated with each approved and investigational indication