Sci (New York NY)
Bhat, N
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Demand exceeded supply for the first several months after launch, leading to periodic shortages
Due to these findings, oral Wegovy would currently be my preferred choice when cardiovascular risk reduction is top priority, says Anton, noting that both medications seem promising for people focused primarily on blood glucose control or creating modest improvements in blood pressure and cholesterol
Preclinical and clinical data, though predominantly derived from case reports and small cohort studies to date, consistently indicate that GLP-1 RAs - including liraglutide, semaglutide, and the dual GIP/GLP-1 RA tirzepatide - can induce clinically meaningful weight loss, suppress the characteristic severe hyperphagia, and improve key cardiometabolic parameters in both heterozygous and homozygous MC4R variant carriers