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In brain ischemia models, GPER expression is upregulated exclusively in males, leading to increased neuronal death

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In SMMC-7721 cells, GA augmented caspase-3, caspase-9, and ROS production, reducing mitochondrial outer membrane permeabilization (MOMP) production, and eventually causing apoptosis

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Synthetic MGF E-domain peptides have been explored for satellite-cell activation in vitro, but no Phase I human safety trial has been completed and published as of the time of this article

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doi: 10.1016/j.it.2020.11.002 55 De FloraS.BalanskyR.La MaestraS

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