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Antitumor effect of organometallic half-sandwich Ru(II)-Arene complexes bearing a glutathione S-Transferase inhibitor

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In vivo studies in mice and rats showed that mitochondrial defects persisted beyond the acute phase of infection, correlating with high mitochondrial ROS (mtROS) levels during chronic disease phase (Wen et al., 2008, 2017

However, current research suggests that daily doses of up to 4 grams are generally safe, even in conjunction with antiplatelet or anticoagulant therapies (82)