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Anticipated Costs Post-Approval While neither compound has reached market, pricing for similar medications provides context: Semaglutide (Wegovy) Approximately $1,300-$1,500 monthly without insurance Tirzepatide (Zepbound) Approximately $1,000-$1,200 monthly without insurance Cagrilintide and retatrutide would likely fall in similar price ranges, with combination therapy potentially costing $2,000-$3,000 monthly without insurance coverage

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The sequence lengths of the TmGsts ranged from 164 (TmGst4) to 406 (TmGst13) amino acids

For context, Zepbound is included on Rightways comprehensive formulary for the 2025 plan year

Sympathetic nerve activity after discrete hypothalamic injections of l-glutamate