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This complete absence of tolerability-driven discontinuations indicates that even when side effects occurred, they were sufficiently mild that participants chose to continue treatment

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Importantly, resting extracellular polyamine concentrations are lower than needed to robustly exert NMDA modulatory effects, and NMDA receptor activation triggers extracellular Spd and Spm release in the striatum (Fage et al., 1992

Important safety considerations include common adverse effects such as gastrointestinal symptoms (nausea, vomiting, diarrhea), which occur in 20-40% of patients but typically diminish with continued use