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One major limitation is the lack of standardized in vivo models and clinically relevant endpoints to assess barrier function, which impedes the translation of preclinical findings into therapeutic or preventive strategies

Balansky R, DAgostini F, Ganchev G et al (2006) Influence of FHIT on benzo[a]pyrene-induced tumors and alopecia in mice: chemoprevention by budesonide and N -acetylcysteine

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Beneath the mucus lies a monolayer of polarized epithelial cells, organized into crypt-villus units that line the luminal surface (Barrett, 2020)

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