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When you lose weight, a lot of things change, Nissen said in an interview Saturday from the conference just after the Wegovy study presentation, which was given to a packed house with several rows of audience members standing at the back

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Weight loss can become noticeable within 4 to 12 weeks of the initial treatment, depending on factors like individual metabolism, diet and physical activity

Evidence most strongly supports continuous therapy as the most reliable long-term approach

The fundamental mechanism of action involves mimicking the physiological effects of endogenous GLP-1, which is secreted by intestinal L-cells in response to food intake

Management of the underlying SLDs typically revolves around etiology-specific interventions: lifestyle modifications (diet, exercise, and weight loss) are the cornerstone for MASLD/MASH