Notes: Due to concern with Torsades de pointes (heart rhythm disturbance), cardiac arrest, and death, do not use higher than recommended doses of loperamide and avoid it in children under age 2
Molfino, M.J
The future of peptide therapeutics appears promising, with technological advances addressing traditional limitations while new applications and mechanisms continue to emerge
Beyond the Somatopause: Growth Hormone Deficiency in Adults Over the Age of 60 Years
Felix and coworkers were pioneers in the site-specific PEGylation of synthetic peptides, a concept that has had diverse medically important applications, such as extending half-lives in the bloodstream of GLP-1 agonists like liraglutide and semaglutide
For example, GI symptoms are more commonly reported when patients are evaluated at a tertiary referral centre compared with a community setting, but allowing for this, estimates suggest up to 70% of people with diabetes are affected