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Our results showed that 10 M BAY 11-7082 effectively inhibited the nuclear translocation of NF-B p65 and the mRNA expression of Bax and P53 , but increased the mRNA expression of Bcl2 and Bcl-xL in the peroxynitrite + BAY 11-7082 group compared with the peroxynitrite-only group, as well as in the peroxynitrite + gpx1 / + BAY 11-7082 group compared with the peroxynitrite + gpx1 / group (Figures 9AC)

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ChaC1 overexpression can augment apoptosis by activating caspase-3/9, degradation of poly (ADP ribose) polymerase, induction of autophagy, ROS generation, increased intracellular calcium and loss of mitochondrial membrane potential (69)

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Chimeric antigen receptor T-cells: an overview of concepts, applications, limitations, and proposed solutions