Medicinal chemistry of adenosine A2A receptor agonists
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Genetic deletion of tumor necrosis factor- attenuates amyloid- production and decreases amyloid plaque formation and glial response in the 5XFAD model of Alzheimers disease
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As an example, GSH depletion has been shown to promote pro-inflammatory microglial phenotypes and amplify astrocyte-microglia crosstalk ( Given these roles, GSH has emerged as a promising therapy and biomarker in neurodegenerative diseases
