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Therefore, large-scale, multi-center randomized controlled trials are needed to evaluate the efficacy and safety of specific antioxidants in diverse patient populations

Instead of the glutathione being treated as a foreign substance that needs to be broken down, the liposome can fuse with the cell membrane, delivering its contents directly

Researchers should design protocols with this translational gap in mind

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It can modulate the activity of enzymes involved in the production of inflammatory mediators, such as lipoxygenase and cyclooxygenase, thus reducing oxidative stress and inflammation [215]

Conclusion Although topical glutathione shows promise for dermatological applications, further larger randomized controlled trials with long-term follow-up are necessary to evaluate its utility more comprehensively in improving hyperpigmentation, erythema, and reducing free-radical damage