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Patients with moderate-to-severe acne, cystic or nodular lesions, scarring, or acne accompanied by signs of hormonal imbalance (irregular menstrual cycles, hirsutism) should be referred to dermatology or endocrinology specialists for comprehensive evaluation and treatment

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The GIP component may further support metabolic function, though the precise contribution of GIP receptor agonism to weight loss and insulin sensitivity in humans remains an area of active research

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